It is also available in combination with pseudoephedrine, a decongestant, known as loratadine/pseudoephedrine. For allergic rhinitis (hay fever), loratadine is effective for both nasal and eye symptoms: sneezing, runny nose, itchy or burning eyes.
Similarly to cetirizine, loratadine attenuates the itching associated with Kimura's disease.
Substances that act as inhibitors of the CYP3A4 enzyme such as ketoconazole, erythromycin, cimetidine, and furanocoumarin derivatives (found in grapefruit) lead to increased plasma levels of loratadine.
This had clinically significant effects in controlled trials of higher-than-usual doses of loratadine (20 mg).
Their main benefit is they primarily affect peripheral histamine receptors and therefore are less sedating.
However, high doses can still induce drowsiness through acting on the central nervous system.
For patients refractive to standard pharmacologic intervention, immunotherapy has shown some promising results.
The effect of desloratadine on newborns/infants is unknown.
Among these are second-generation antihistamines and anticholinergic agents, intranasal corticosteroids, and mast cell stabilizers.
Recently, montelukast, a leukotriene receptor antagonist, has been added to the modes of therapy approved by the US Food and Drug Administration for allergic rhinitis.
Loratadine, sold under the brand name Claritin among others, is a medication used to treat allergies.
This includes allergic rhinitis (hay fever) and hives.